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Thermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides.

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Ibrahimova, Vusala | Zhao, Hang | Ibarboure, Emmanuel | Garanger, Elisabeth | Lecommandoux, Sébastien

Edité par CCSD ; Wiley-VCH Verlag -

International audience. Biomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin-like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein-based membranes. In addition to the bioengineered post-translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush-like lipid-grafted-ELPs using chemical post-modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature-responsiveness of ELPs.

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