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SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations

Archive ouverte | Paccoud, Romain | CCSD

International audience. Hyperactive SHP2 promotes inflammation-driven insulin resistance by skewing macrophage balance in metabolic tissues and may be a target in T2D.

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature

Archive ouverte | Serra-Nédélec, Audrey de Rocca | CCSD

Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 (PTPN11), is characterized by congenital cardiopathies, facial dysmorphic features, and short stature. How mu...

The exerkine apelin reverses age-associated sarcopenia

Archive ouverte | Vinel, Claire | CCSD

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition often responsible for the medical institu...

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