Afficher la couverture 'A novel minimal motif for left-handed G-quadruplex formation | Das, Poulomi' en grand format
/5

0 avis

A novel minimal motif for left-handed G-quadruplex formation

Archive ouverte

Das, Poulomi | Winnerdy, Fernaldo Richtia | Maity, Arijit | Mechulam, Yves | Phan, Anh Tuân

Edité par CCSD ; Royal Society of Chemistry -

International audience. A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

Suggestions

Du même auteur

Bulges in left-handed G-quadruplexes

Archive ouverte | Das, Poulomi | CCSD

International audience. G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequis...

NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes

Archive ouverte | Winnerdy, Fernaldo Richtia | CCSD

International audience. Analogous to the B- and Z-DNA structures in double-helix DNA, there exist both right- and left-handed quadruple-helix (G-quadruplex) DNA. Numerous conformations of right-handed and a few left...

Unprecedented hour-long residence time of a cation in a left-handed G-quadruplex

Archive ouverte | Winnerdy, Fernaldo Richtia | CCSD

International audience. An extremely long-lived cation has been detected in left-handed G-quadruplexes.

Chargement des enrichissements...