Nasal high-frequency percussive ventilation vs nasal continuous positive airway pressure in newborn infants respiratory distress: A cross over clinical trial. : Pediatr Pulmonol

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Renesme, L. | Dumas de La Roque, E. | Germain, C. | Chevrier, A. | Rebola, M. | Cramaregeas, S. | Benard, Antoine | Elleau, C. | Tandonnet, O.

Edité par CCSD ; Wiley -

International audience. OBJECTIVE: To determine if nasal high-frequency percussive ventilation (nHFPV) to manage neonatal respiratory distress decreases the regional cerebral oxygen saturation (rScO(2) ) compared to nasal CPAP. STUDY DESIGN: A prospective, randomized, monocentric, open-label, non-inferiority crossover trial. Newborns of gestational age (GA) ≥ 33 weeks exhibiting persistent respiratory distress after 10 min of life were treated with nHFPV and nCPAP, in succession and in random order. The primary endpoint was the mean rScO(2) , as revealed by near-infrared spectroscopy (NIRS). RESULTS: Forty-nine newborns were randomized; the mean GA and birth weight were 36.4 ± 1.9 weeks and 2,718 ± 497 g. The mean rScO(2) difference during the last 5 min of each ventilation mode (nHFPV minus nCPAP) was -0.7 ± 5.4% (95% CI -2.25; 0.95%). CONCLUSION: In our study on newborns of GA ≥ 33 weeks treated for respiratory distress, cerebral oxygenation via nHFPV was not inferior to nCPAP. This article is protected by copyright. All rights reserved.

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