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An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

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Gonzalez-Menendez, Pedro | Romano, Manuela | Yan, Hongxia | Deshmukh, Ruhi | Papoin, Julien | Oburoglu, Leal | Daumur, Marie | Dumé, Anne-Sophie | Phadke, Ira | Mongellaz, Cédric | Qu, Xiaoli | Bories, Phuong-Nhi | Fontenay, Michaela | An, Xiuli | Dardalhon, Valérie | Sitbon, Marc | Zimmermann, Valérie | Gallagher, Patrick, G | Tardito, Saverio | Blanc, Lionel | Mohandas, Narla | Taylor, Naomi | Kinet, Sandrina

Edité par CCSD ; Elsevier Inc -

International audience. Highlights d Glutamine-dependent OXPHOS drives early erythroid differentiation d OXPHOS-induced ROS inhibit erythroblast enucleation d IDH1 downregulation augments ROS, leading to pathological erythroid differentiation d Vitamin C rescues erythroid differentiation under conditions of oxidative stress

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