B cells and cancer: To B or not to B?

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Fridman, Wolf Herman | Petitprez, Florent | Meylan, Maxime | Chen, Tom Wei-Wu | Sun, Cheng-Ming | Roumenina, Lubka, T | Sautès-Fridman, Catherine

Edité par CCSD ; Rockefeller University Press -

International audience. Whereas T cells have been considered the major immune cells of the tumor microenvironment able to induce tumor regression and control cancer clinical outcome, a burst of recent publications pointed to the fact that B cells may also play a prominent role. Activated in germinal centers of tertiary lymphoid structures, B cells can directly present tumor-associated antigens to T cells or produce antibodies that increase antigen presentation to T cells or kill tumor cells, resulting in a beneficial clinical impact. Immune complexes can also increase inflammation, angiogenesis, and immunosuppression via macrophage and complement activation, resulting in deleterious impact.

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