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Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Archive ouverte | Hoyles, Lesley | CCSD

International audience. Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal me...

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Archive ouverte | Mayneris-Perxachs, Jordi | CCSD

International audience. Background: The gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear...

ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids

Archive ouverte | Menghini, Rossella | CCSD

International audience. Objective: Metabolic syndrome, obesity, and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging proteins for degradation. The identification...

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