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A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles.

Archive ouverte | Delelis, Olivier | CCSD

Retroviral integration is central to viral persistence and pathogenesis, cancer as well as host genome evolution. However, it is unclear why integration appears essential for retrovirus production, especially given the abundance a...

Inhibition of Early Steps of HIV-1 Replication by SNF5/Ini1

Archive ouverte | Maroun, Marlène | CCSD

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Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.

Archive ouverte | Delelis, Olivier | CCSD

BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA. It is widely assumed that the strand...

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