CMIP is a negative regulator of T cell signaling

Archive ouverte

Oniszczuk, Julie | Sendeyo, Kelhia | Chhuon, Cerina | Savas, Berkan | Cogné, Etienne | Vachin, Pauline | Hénique, Carole | Guerrera, Ida, Chiara | Astarita, Giuseppe | Frontera, Vincent | Pawlak, Andre | Audard, Vincent | Sahali, Dil | Ollero, Mario, M.

Edité par CCSD ; Nature Publishing Group/Chinese Society of Immunology -

International audience. Upon interaction with cognate antigen, T cells integrate different extra and intracellular signals, involving basal and induced protein-protein interactions as well as binding of proteins to lipids, which can lead to either cell activation or inhibition. Here we show that selective T-cell expression of CMIP, a new adaptor protein, by targeted transgenesis drives

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion