Suggestions

Du même auteur

LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

Archive ouverte | Proteau, Sarah | CCSD

International audience. Abstract Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the...

Recent advances in understanding the role of HES6 in cancers

Archive ouverte | Krossa, Imène | CCSD

International audience. The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH ...

Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells

Archive ouverte | Bellini, Lara | CCSD

International audience. To address unmet clinical need for uveal melanomas, we assessed the effects of BH3-mimetic molecules, the ABT family, known to exert pro-apoptotic activities in cancer cells. Our results unco...

Chargement des enrichissements...