Nuclear Pore Complexes, Genome Organization and HIV-1 Infection

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Di Nunzio, Francesca

Edité par CCSD ; Springer International Publishing -

International audience. Nuclear pore complexes (NPCs) are dynamic structures embedded in double lipid layer of the nuclear envelope (NE), which act as guardians of nucleocytoplasmic transport, and contribute to genome organization, genome stability and gene expression regulation. Some of these cellular functions orchestrated by NPCs are usurped by viruses that replicate in the nucleus. Non-mitotic cells are one of the major targets of HIV-1, thus the passage of the virus through the NPC is a key step for viral replication. In recent years, research regarding multiple aspects of the early steps of HIV-1 life cycle highlights dynamic and concerted interactions between viral components, NPC and chromatin state. HIV-1 is a member of this host-pathogen activity which ensures favourable conditions for the production of its own progeny. This chapter aims to review the existing and emerging concepts showing how individual nucleoporins (Nups) may be a “cellular code” that dictates HIV-1 fate in infected cells.

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