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Genome-Scale Analysis of Metazoan Replication Origins Reveals their Organization in Specific but Flexible Sites Defined by Conserved Features

Archive ouverte | Cayrou, Christelle | CCSD

International audience. In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive. Here, we characterized Oris by ...

Involvement of G-quadruplex regions in mammalian replication origin activity

Archive ouverte | Prorok, Paulina | CCSD

International audience. Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4). Here, we ...

The chromatin environment shapes DNA replication origin organization and defines origin classes

Archive ouverte | Cayrou, Christelle | CCSD

International audience. To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high-resolution in mouse ES cells. This allowed initiation sites (IS) a...

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