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High-Dimensional Phenotyping of Human Myeloid-Derived Suppressor Cells/Tumor-Associated Macrophages in Tissue by Mass Cytometry

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Ferrant, Juliette | Le Gallou, Simon | Manson, Guillaume | Genebrier, Steve | Mourcin, Frédéric | Tarte, Karin | Roussel, Mikaël

Edité par CCSD ; Humana Press/Springer Imprint -

International audience. Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are heterogeneous cells that share myeloid markers and are not easily distinguishable in human tumors due to their lack of specific markers. These cells are a major player in the tumor microenvironment and are involved in the prognosis and physiopathology of various tumors. Here is presented a scheme to decipher these cells by mass cytometry.

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