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Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis

Archive ouverte | Chehaitly, Ahmad | CCSD

International audience. Flow (shear stress)-mediated dilation (FMD) of resistance arteries is a rapid endothelial response involved in tissue perfusion. FMD is reduced early in cardiovascular diseases, generating a ...

Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

Archive ouverte | Favre, Julie | CCSD

International audience. Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action whereas plasma membrane-located ERα accelerates endothelial healing. The genetic deficiency ...

Nuclear Activation Function 2 Estrogen Receptor α Attenuates Arterial and Renal Alterations Due to Aging and Hypertension in Female Mice

Archive ouverte | Guivarc'H, Emmanuel | CCSD

International audience. BackgroundThe cardiovascular protective effects of estrogens in premenopausal women depend mainly on estrogen receptor α (ERα). ERα activates nuclear gene transcription regulation and membran...

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