Suggestions

Du même auteur

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches

Archive ouverte | Soleilhac, Emmanuelle | CCSD

International audience. Dinitroanilines are chemical compounds with high selectivity for plant cell -tubulin in which they promote microtubule depolymerization. They target -tubulin regions that have diverged over e...

Pharmacological inhibition of LIM Kinase stabilizes microtubules and inhibits neoplastic growth

Archive ouverte | Prudent, Renaud | CCSD

International audience. The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to scree...

Novel synthetic pharmacophores inducing a stabilization of cellular microtubules

Archive ouverte | Martinez, Anne | CCSD

International audience. Microtubule drugs have been widely used in cancer chemotherapies. Although microtubules are subject to regulation by signal transduction mechanisms, their pharmacological modulation has so fa...

Chargement des enrichissements...