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Tau as a biomarker of neurodegenerative diseases.

Archive ouverte | Schraen-Maschke, Susanna | CCSD

International audience. The microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegene...

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

Archive ouverte | Ando, Kunie | CCSD

International audience. A prerequisite to dephosphorylation at Ser-Pro or Thr-Pro motifs is the isomerization of the imidic peptide bond preceding the proline. The peptidyl-prolyl cis/trans isomerase named Pin1 cata...

The MAPT gene is differentially methylated in the progressive supranuclear palsy brain. Le gène MAPT est méthylé différentiellement dans le cerveau dans la paralysie supranucléaire progressive. The MAPT gene is differentially methylated in the progressive supranuclear palsy brain: Hypomethylation of MAPT in PSP brain. Le gène MAPT est méthylé différentiellement dans le cerveau dans la paralysie supranucléaire progressive: Hypométhylation de la MAPT dans le cerveau des PSP

Archive ouverte | Huin, Vincent | CCSD

International audience. Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene corr...

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