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Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress

Archive ouverte | Bodnar-Wachtel, Mélanie | CCSD

International audience. NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory d...

NLRP3 controls ATM activation in response to DNA damage

Archive ouverte | Bodnar-Wachtel, Mélanie | CCSD

The DNA damage response (DDR) is essential to preserve genomic integrity and acts as a barrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strand breaks (DSBs), and its attenuation is frequent durin...

CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

Archive ouverte | Sanlaville, Amélien | CCSD

ABSTRACT Epithelial-mesenchymal transition (EMT) is a central oncogenic mechanism, contributing both to transformation and metastatic dissemination. Inflammation and innate immune cells are known to favor EMT induction, but the ro...

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