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SFPH proteins as therapeutic targets for a myriad of diseases

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Wang, Dong | Tabti, Redouane | Elderwish, Sabria | Djehal, Amel | Chouha, Nora | Pinot, Franck | Yu, Peng | Nebigil, Canan G | Desaubry, Laurent

Edité par CCSD ; Elsevier -

International audience. The stomatin/prohibitin/flotillin/HflK/HflC (SPFH) domain is present in an evolutionarily conserved family of proteins that regulate a myriad of signaling pathways in archaea, bacteria and eukaryotes. The most studied SPFH proteins, prohibitins, have already been targeted by different families of small molecules to induce anticancer, cardioprotective, anti-inflammatory, antiviral, and antiosteoporotic activities. Ligands of other SPFH proteins have also been identified and shown to act as anesthetics, anti-allodynia, anticancer, and anti-inflammatory agents. These findings indicate that modulators of human or bacterial SPFH proteins can be developed to treat a wide variety of human disorders.

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