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Polymerase III transcription is necessary for T cell priming by dendritic cells

Archive ouverte | Reverendo, Marisa | CCSD

International audience. Exposure to microbe-associated molecular patterns (MAMPs) causes dendritic cells (DCs) to undergo a remarkable activation process characterized by changes in key biochemical mechanisms. These...

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages

Archive ouverte | Valečka, Jan | CCSD

International audience. We report here that RUFY4, a newly characterized member of the ‘RUN and FYVE domain-containing’ family of proteins previously associated with autophagy enhancement, is highly expressed in alv...

Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA

Archive ouverte | Dalet, Alexandre | CCSD

International audience. In innate immune responses, induction of type-I interferons (IFNs) prevents virus spreading while viral replication is delayed by protein synthesis inhibition. We asked how cells perform thes...

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