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Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

Archive ouverte | Zvezdova, Ekaterina | CCSD

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THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals

Archive ouverte | Yang, Cui | CCSD

International audience. Signals that determine the differentiation of naïve CD4 + T helper (T H ) cells into specific effector cell subsets are primarily stimulated by cytokines, but additional signals are required ...

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.

Archive ouverte | Duguet, Fanny | CCSD

Regulatory T cells (Treg) represent a minor subpopulation of T lymphocytes that is crucial for the maintenance of immune homeostasis. Here, we present a large-scale quantitative mass spectrometry study that defines a specific prot...

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