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SAMHD1 acts at stalled replication forks to prevent interferon induction. SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron

Archive ouverte | Coquel, F. | CCSD

International audience. DNA replication is an extremely complex process, involving thousands of replication forks progressing along chromosomes. These forks are requently slowed down or stopped by various obstacles...

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

Archive ouverte | Charpentier, M. | CCSD

International audience. In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent ...

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.

Archive ouverte | Lewis, M. | CCSD

International audience. Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive org...

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