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Structural basis of orientated asymmetry in a mGlu heterodimer

Archive ouverte | Huang, Weizhu | CCSD

International audience. The structural basis for the allosteric interactions within G protein-coupled receptors (GPCRs) heterodimers remains largely unknown. The metabotropic glutamate (mGlu) receptors are complex d...

Asymmetric activation of dimeric GABA B and metabotropic glutamate receptors

Archive ouverte | Liu, Lei | CCSD

International audience. G protein-coupled receptors (GPCRs) represent the largest family of membrane proteins and are important drug targets. GPCRs are allosteric machines that transduce an extracellular signal to t...

Structural basis of GABAB receptor–Gi protein coupling

Archive ouverte | Shen, Cangsong | CCSD

International audience. G-protein-coupled receptors (GPCRs) have central roles in intercellular communication1,2. Structural studies have revealed how GPCRs can activate G proteins. However, whether this mechanism i...

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