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Atovaquone exposure and Pneumocystis jirovecii cytochrome b mutations: French data and review of the literature

Archive ouverte | Bonnet, Pierre | CCSD

International audience. Abstract Pneumocystis jirovecii is a transmissible fungus responsible for severe pneumonia (Pneumocystis pneumonia [PCP]) in immunocompromised patients. Missense mutations due to atovaquone s...

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Archive ouverte | Bonnet, Pierre | CCSD

International audience. Echinocandins are noncompetitive inhibitors of the GSC1 subunit of the enzymatic complex involved in synthesis of 1,3-beta- d -glucan, a cell wall component of most fungi, including Pneumocys...

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Archive ouverte | Hoffmann, Claire, V | CCSD

International audience. Mycophenolic acid (MPA) targets the inosine 5′-monophosphate dehydrogenase (IMPDH) of human lymphocytes. It is widely used as an immunosuppressant to prevent rejection in solid organ transpla...

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