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Altered Cholesterol Homeostasis in Huntington’s Disease

Archive ouverte | Kacher, Radhia | CCSD

International audience. Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated neurodegeneration mainly af...

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Archive ouverte | Boussicault, Lydie | CCSD

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Archive ouverte | Kacher, Radhia | CCSD

International audience. Abstract Dysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The main pathway for brain cholesterol elimination is its hydroxylation into 24S-hydro...

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