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Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells

Archive ouverte | Sawai, Catherine, M | CCSD

International audience. Plasmacytoid dendritic cells (pDCs) rapidly produce type I interferon (IFN-I) in response to viruses and are essential for antiviral immune responses. Although related to classical DCs (cDCs)...

Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction

Archive ouverte | Chan, Rebecca, W y | CCSD

International audience. Plasma DNA fragmentomics is an emerging area in cell-free DNA diagnostics and research. In murine models, it has been shown that the extracellular DNase, DNASE1L3, plays a role in the fragmen...

Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus

Archive ouverte | Hartl, Johannes | CCSD

International audience. Antibodies to double-stranded DNA (dsDNA) are prevalent in systemic lupus erythematosus (SLE), particularly in patients with lupus nephritis, yet the nature and regulation of antigenic cell-f...

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