Afficher la couverture 'Interaction of smoking and radon in rats: A biologically based mechanistic model | Heidenreich, W.F.' en grand format
/5

0 avis

Interaction of smoking and radon in rats: A biologically based mechanistic model

Archive ouverte

Heidenreich, W.F. | Morlier, J.P. | Monchaux, G.

Edité par CCSD ; Springer Verlag -

International audience. Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acting on transformation and inducing a reduction of the radon dose to the target cells after a smoking period gives an acceptable description of the data. © Springer-Verlag 2005.

Consulter en ligne

Suggestions

Du même auteur

Lung tumour risk in radon-exposed rats from different experiments: Comparative analysis with biologically based models

Archive ouverte | Kaiser, J.C. | CCSD

International audience. Data sets of radon-exposed male rats from Wistar and Sprague-Dawley strains have been investigated with two different versions of the two-step clonal expansion (TSCE) model of carcinogenesis....

Age-adjustment in experimental animal data and its application to lung cancer in radon-exposed rats

Archive ouverte | Heidenreich, W.F. | CCSD

International audience. Procedures for age-adjustment of cancer fractions are proposed which do not require fixed age intervals. The full available information on survival times can then be used, which is especially...

Lung cancer mortality in the European uranium miners cohorts analyzed with a biologically based model taking into account radon measurement error

Archive ouverte | Heidenreich, W.F. | CCSD

International audience. The biologically based two-stage clonal expansion (TSCE) model is used to analyze lung cancer mortality of European miners from the Czech Republic, France, and Germany. All three cohorts indi...

Chargement des enrichissements...