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Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

Archive ouverte | Vilette, Didier | CCSD

International audience. Exosomes are secreted membrane vesicles of endosomal origin present in biological fluids. Exosomes may serve as shuttles for amyloidogenic proteins, notably infectious prions, and may partici...

Prion strains are differentially released through the exosomal pathway

Archive ouverte | Arellano Anaya, Zaïra Esperanza | CCSD

International audience. Cell-to-cell transfer of prions is a crucial step in the spreading of prion infection through infected tissue. At the cellular level, several distinct pathways including direct cell-cell cont...

Isolation of Exosomes and Microvesicles from Cell Culture Systems to Study Prion Transmission.

Archive ouverte | Leblanc, Pascal | CCSD

International audience. Extracellular vesicles (EVs) are composed of microvesicles and exosomes. Exosomes are small membrane vesicles (40-120 nm sized) of endosomal origin released in the extracellular medium from c...

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