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Insight into DNA substrate specificity of PARP1 catalyzed DNA poly(ADP-ribosyl)ation

Archive ouverte | Matta, Elie | CCSD

International audience. Poly(ADP-ribose) polymerases (PARPs) use nicotine adenine dinucleotide as substrate to synthetize monomer or a branched polymer of ADP-ribose (MAR or PAR, respectively) covalently attached to...

Identification of potential readers of DNA-ADPr adducts in cell-free extracts

Archive ouverte | Matta, Elie | CCSD

International audience. Poly- and mono-ADP-ribosylation catalyzed by poly(ADP-ribose) polymerases (PARPs) is a highly conserved post-translational modification of proteins involved in DNA damage recognition, signali...

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Archive ouverte | Schellenbauer, Amelie | CCSD

International audience. Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of Ku70 at ser27-se...

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