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Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production

Archive ouverte | Metghalchi, Sarvenaz | CCSD

International audience. Indoleamine 2,3-dioxygenase 1 (Ido1) is a rate-limiting enzyme that catalizes the degradation of tryptophan along the kynurenine pathway. Here, we show that Ido1 activity sustains an immunost...

Genetic deficiency of Indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Archive ouverte | Laurans, Ludivine | CCSD

International audience. The association between altered gut microbiota, intestinal permeability, inflammation and cardiometabolic diseases is becoming increasingly clear but remains poorly understood1,2. Indoleamine...

Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry.

Archive ouverte | Wallet, Hélène Labussière | CCSD

International audience. : Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological malignancies for which umbilical cord blood (UCB) represents an alternative source o...

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