Comparison of dengue case classification schemes and evaluation of biological changes in different dengue clinical patterns in a longitudinal follow-up of hospitalized children in Cambodia

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Dussart, Philippe | Duong, Veasna | Bleakley, Kevin | Fortas, Camille | Try, Patrich Lorn | Kim, Kim Sroin | Choeung, Rithy | In, Saraden | Andries, Anne-Claire | Cantaert, Tineke | Flamand, Marie | Buchy, Philippe | Sakuntabhai, Anavaj

Edité par CCSD ; Public Library of Science -

International audience. The World Health Organization (WHO) proposed guidelines on dengue clinical classification in 1997 and more recently in 2009 for the clinical management of patients. The WHO 1997 classification defines three categories of dengue infection according to severity: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Alternative WHO 2009 guidelines provide a cross-sectional classification aiming to discriminate dengue fever from dengue with warning signs (DWWS) and severe dengue (SD). The primary objective of this study was to perform a comparison of two dengue classifications. The secondary objective was to describe the changes of hematological and biochemical parameters occurring in patients presenting with different degrees of severity during the course of the disease, since progression to more severe clinical forms is unpredictable.

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