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Intramolecular T cell spreading in unprimed MRL/lpr mice: Importance of the U1-70k protein sequence 131-151

Archive ouverte | Monneaux, Fanny | CCSD

International audience

Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Faslpr and (NZB × NZW)F1 lupus mice

Archive ouverte | Monneaux, Fanny | CCSD

International audience

Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus.

Archive ouverte | Monneaux, Fanny | CCSD

We previously demonstrated the importance of the RNP1 motif-bearing region 131-151 of the U1-70K spliceosomal protein in the intramolecular T-B spreading that occurs in MRL/lpr lupus mice. Here, we analyze the involvement of RNP1 ...

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