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Contributions of selective knockout studies to understanding cholinesterase disposition and function

Archive ouverte | Camp, Shelley | CCSD

International audience. The complete knockout of the acetylcholinesterase gene (AChE) in the mouse yielded a surprising phenotype that could not have been predicted from deletion of the cholinesterase genes in Droso...

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

Archive ouverte | Peng, Hong | CCSD

International audience. Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. Pairing analysis in the Octet system identifi...

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Archive ouverte | Peng, Hong | CCSD

International audience. Human butyrylcholinesterase (HuBChE) is a stoichiometric bioscavenger of nerve agents and organophosphorus pesticides. Mass spectrometry methods detect stable nerve agent adducts on the activ...

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