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Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes

Archive ouverte | Piperno, Giulia, Maria | CCSD

International audience. Dysregulated sensing of self–nucleic acid is a leading cause of autoimmunity in multifactorial and monogenic diseases. Mutations in Wiskott-Aldrich syndrome protein (WASp), a key regulator of...

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Archive ouverte | Caronni, Nicoletta | CCSD

International audience. Abstract Acquisition of cell-associated tumor antigens by type 1 dendritic cells (cDC1) is essential to induce and sustain tumor specific CD8 + T cells via cross-presentation. Here we show th...

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

Archive ouverte | López, Lucía | CCSD

International audience. Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presentin...

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