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The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition

Archive ouverte | Grelet, Simon | CCSD

International audience. In this study, we explore the role of the human NANOS3 germline gene in lung tumour progression. We report that Nanos3 is overexpressed by invasive lung cancer cells and represents a new prog...

{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation.

Archive ouverte | Maouche, Kamel | CCSD

International audience. Airway epithelial basal cells are known to be critical for regenerating injured epithelium and maintaining tissue homeostasis. Recent evidence suggests that the alpha7 nicotinic acetylcholine...

alpha3alpha5beta2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells

Archive ouverte | Tournier, Jean-Marie | CCSD

Nicotinic acetylcholine receptors (nAChRs), present in human bronchial epithelial cells (HBECs), have been shown in vitro to modulate cell shape. Because cell spreading and migration are important mechanisms involved in the repair...

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