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The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division

Archive ouverte | Lemonnier, Tom | CCSD

International audience. Oocytes are held in meiotic prophase for prolonged periods until hormonal signals trigger meiotic divisions. Key players of M-phase entry are the opposing Cdk1 kinase and PP2A-B55δ phosphatas...

Cross-species analysis of ARPP19 phosphorylation during oocyte meiotic maturation charts the emergence of a new cAMP-dependent role in vertebrates

Archive ouverte | Meneau, Ferdinand | CCSD

In many animal species, elevated cAMP-PKA signaling initiates oocyte meiotic maturation upon hormonal stimulation, whereas in vertebrates, it acts as a negative regulator of this process. To address this “cAMP paradox”, we have fo...

Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation

Archive ouverte | Santoni, Martina | CCSD

International audience. Santoni et al. identify multiple pathways connecting PKA downregulation to Cdk1 activation and controlling G2/M transition in oocytes. Among the events taking place upstream of Cdk1 activatio...

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