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reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila

Archive ouverte | Brun, Sylvain | CCSD

International audience. bcl-2 was the first regulator of apoptosis shown to be involved in oncogenesis. Subsequent studies in mammals, in the nematode and in Drosophila revealed wide evolutionary conservation of the...

The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the b-TrCP homologue slimb

Archive ouverte | Colin, Jessie | CCSD

International audience. The ubiquitin-proteasome system is one of the main proteolytic pathways. It inhibits apoptosis by degrading pro-apoptotic regulators, such as caspases or the tumor suppressor p53. However, it...

The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells

Archive ouverte | Milet, Cecile | CCSD

International audience. The retinoblastoma protein, pRb, plays important roles in many processes implicated in cell fate decisions, including cell cycle, differentiation and apoptosis. In cell cycle regulation, pRb ...

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