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Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?

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Aubart, Melodie | Gitiaux, Cyril | Roux, Charles Joris | Levy, Raphael | Schuffenecker, Isabelle | Mirand, Audrey | Bach, Nathalie | Moulin, Florence | Bergounioux, Jean | Leruez-Ville, Marianne | Rozenberg, Flore | Sterlin, Delphine | Musset, Lucile | Antona, Denise | Boddaert, Nathalie | Zhang, Shen Ying | Kossorotoff, Manoelle | Desguerre, Isabelle

Edité par CCSD ; Frontiers Media -

International audience. Acute flaccid myelitis (AFM) is an acute paralysis syndrome defined by a specific inflammation of the anterior horn cells of the spinal cord. From 2014, worrying waves of life-threatening AFM consecutive to enterovirus infection (EV-D68 and EV-A71) have been reported. We describe 10 children displaying an AFM with an EV infection, the treatments performed and the 1 to 3-years follow-up. Two groups of patients were distinguished: 6 children (“polio-like group”) had severe motor disability whereas 4 other children (“brainstem group”) displayed severe brainstem weakness requiring ventilation support. Electrodiagnostic studies (n = 8) support the presence of a motor neuronopathy associated to myelitis. The best prognosis factor seems to be the motor recovery after the first 4 weeks of the disease.

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