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Both normal and polyglutamine- expanded ataxin-7 are comp- onents of TFTC-type GCN5 histone acetyltransferase- containing complexes

Archive ouverte | Helmlinger, Dominique | CCSD

International audience. SCA7 (spinocerebellar ataxia type 7) is a neurodegenerative disorder caused by a CAG repeat expansion in the SCA7 gene that leads to elongation of a polyglutamine tract in ataxin-7, a protein...

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

Archive ouverte | Yvert, G. | CCSD

International audience

Polyglutamine Expansion Induces a Protein-damaging Stress Connecting Heat Shock Protein 70 to the JNK Pathway

Archive ouverte | Mérienne, Karine | CCSD

International audience. Polyglutamine diseases, including Huntington's disease , designate a group of nine neurodegenerative disorders characterized by the presence of a toxic polyglu-tamine expansion in specific ta...

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