Alpha technology: A powerful tool to detect mouse brain intracellular signaling events

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Zanese, Marion | Tomaselli, Giovanni | Roullot-Lacarrière, Valérie | Moreau, Maïté | Bellocchio, Luigi | Grel, Agnès | Marsicano, Giovanni | Sans, Nathalie | Vallée, Monique | Revest, Jean-Michel

Edité par CCSD ; Elsevier -

International audience. Phosphorylation by protein kinases is a fundamental molecular process involved in the regulation of signaling activities in living organisms. Understanding this complex network of phosphorylation, especially phosphoproteins, is a necessary step for grasping the basis of cellular pathophysiology. Studying brain intracellular signaling is a particularly complex task due to the heterogeneous complex nature of the brain tissue, which consists of many embedded structures.

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