Afficher la couverture 'Dendritic Spine Plasticity: Function and Mechanisms | Runge, Karen' en grand format
/5

0 avis

Dendritic Spine Plasticity: Function and Mechanisms

Archive ouverte

Runge, Karen | Cardoso, Carlos | de Chevigny, Antoine

Edité par CCSD ; Frontiers Media -

International audience. Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888 by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of electron microscopy (EM) confirmed Cajal's intuition that spines constitute the postsynaptic site of most excitatory synapses in the mammalian brain. The finding that spine density decreases between young and adult ages in fixed tissues suggested that spines are dynamic. It is only a decade ago that two-photon microscopy (TPM) has unambiguously proven the dynamic nature of spines, through the repeated imaging of single spines in live animals. Spine dynamics comprise formation, disappearance, and stabilization of spines and are modulated by neuronal activity and developmental age. Here, we review several emerging concepts in the field that start to answer the following key questions: What are the external signals triggering spine dynamics and the molecular mechanisms involved? What is, in return, the role of spine dynamics in circuit-rewiring, learning, and neuropsychiatric disorders?

Suggestions

Du même auteur

Disruption of NEUROD2 causes a neurodevelopmental syndrome with autistic features via cell-autonomous defects in forebrain glutamatergic neurons

Archive ouverte | Runge, Karen | CCSD

International audience. While the transcription factor NEUROD2 has recently been associated with epilepsy, its precise role during nervous system development remains unclear. Using a multi-scale approach, we set out...

Disruption of the transcription factor NEUROD2 causes an autism syndrome via cell-autonomous defects in cortical projection neurons

Archive ouverte | Runge, Karen | CCSD

We identified seven families associating NEUROD2 pathogenic mutations with ASD and intellectual disability. To get insight into the pathophysiological mechanisms, we analyzed cortical development in Neurod2 KO mice. Cortical proje...

Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

Archive ouverte | Faure, Louis | CCSD

International audience. Somatic sensation is defined by the existence of a diversity of primary sensory neurons with unique biological features and response profiles to external and internal stimuli. However, there ...

Chargement des enrichissements...