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Depletion of CD11c + cells in the CD11c.DTR model drives expansion of unique CD64 + Ly6C + monocytes that are poised to release TNF-α

Archive ouverte | Sivakumaran, Shivajanani | CCSD

International audience. Dendritic cells (DCs) play a vital role in innate and adaptive immunities. Inducible depletion of CD11c(+) DCs engineered to express a high-affinity diphtheria toxin receptor has been a power...

Mobilized Multipotent Hematopoietic Progenitors Promote Expansion and Survival of Allogeneic Tregs and Protect Against Graft Versus Host Disease

Archive ouverte | d'Aveni, Maud | CCSD

International audience. Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) is routinely performed with peripheral blood stem cells (PBSCs) mobilized by injection of G-CSF, a growth factor which not only ...

Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis

Archive ouverte | Korniotis, Sarantis | CCSD

International audience. Achieving immunoregulation via in vivo expansion of Foxp3+ regulatory CD4+ T cells (Treg) remains challenging. We have shown that mobilization confers to multipotent hematopoietic progenitors...

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