Tracking Crystallophore Nucleating Properties: Setting Up a Database for Statistical Analysis

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Jiang, Tao | Roux, Amandine | Engilberge, Sylvain | Alsalman, Zaynab | Di Pietro, Sebastiano | Franzetti, Bruno | Riobé, François | Maury, Olivier | Girard, Eric

Edité par CCSD ; American Chemical Society -

International audience. In this article, the principle of a database aimed at facilitating the understanding of the unique protein nucleating properties of the crystallophore is presented. A first analysis allows us to compare the efficiency of Tb-Xo4 with the new Lu-Xo4 variant, featuring improved phasing properties. Then, the concept of subset-of-interest is introduced to reveal potential antagonistic/synergistic effects between Tb-Xo4 and physicochemical parameters of the crystallization kits such as pH. The overall approach may be of interest for any studies working on solutions dedicated to improve the nucleating step in protein crystallization.

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