Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

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Kliemann, Nathalie | Murphy, Neil | Viallon, Vivian | Freisling, Heinz | Tsilidis, Konstantinos K. | Rinaldi, Sabina | Mancini, Francesca Romana | Fagherazzi, Guy | Boutron-Ruault, Marie Christine | Boeing, Heiner | Schulze, Matthias B. | Masala, Giovanna | Krogh, Vittorio | Sacerdote, Carlotta | de Magistris, Maria | Bueno-De-Mesquita, Bas H. | Weiderpass, Elisabete | Kühn, Tilman | Kaaks, Rudolf J. | Jakszyn, Paula G. | Redondo-Sánchez, Daniel | Amiano, Pilar | Chirlaque, María Dolores | Gurrea, Aurelio Barricarte | Ericson, Ulrika C. | Drake, Isabel | Nøst, Therese Haugdahl | Aune, Dagfinn | May, Anne Maria | Tjønneland, Anne | Dahm, Christina C. | Overvad, Kim | Tumino, Rosario | Quirós, Josè Ramón | Trichopoulou, Antonia D. | Karakatsani, Anna | La Vecchia, Carlo | Nilsson, Lena Maria | Riboli, Elio | Huybrechts, Inge | Gunter, Marc J.R.

Edité par CCSD ; Wiley -

International audience. Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

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