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Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis

Archive ouverte | Payros, Delphine | CCSD

International audience. The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyz...

Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

Archive ouverte | Massip, Clémence | CCSD

International audience. Although Escherichia coli Nissle 1917 (EcN) has been used therapeutically for over a century, the determinants of its probiotic properties remain elusive. EcN produces two siderophore-microci...

Escherichia coliClbS is a colibactin resistance protein

Archive ouverte | Bossuet-Greif, Nadège | CCSD

International audience. The genomic pks island codes for the biosynthetic machinery that produces colibactin, a peptide-polyketide metabolite. Colibactin is a genotoxin that contributes to the virulence of extra-int...

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