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The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants. The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants: UvrD acts at arrested replication forks

Archive ouverte | Flores, Maria-Jose | CCSD

International audience. Replication forks arrested by inactivation of the main Escherichia coli DNA polymerase (polymerase III) are reversed by the annealing of newly synthesized leading‐ and lagging‐strand ends. Re...

A fork-clearing role for UvrD

Archive ouverte | Flores, Maria-Jose | CCSD

International audience. The inactivation of a replication protein causes the disassembly of the replication machinery and creates a need for replication reactivation. In several replication mutants, restart occurs a...

Multiple pathways process stalled replication forks

Archive ouverte | Michel, Bénédicte | CCSD

International audience. Impairment of replication fork progression is a serious threat to living organisms and a potential source of genome instability. Studies in prokaryotes have provided evidence that inactivated...

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