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Tumor resistance to radiotherapy is triggered by an ATM/TAK1-dependent-increased expression of the cellular prion protein

Archive ouverte | Bernardino-Sgherri, Jacqueline | CCSD

International audience. In solid cancers, high expression of the cellular prion protein (PrPC) is associated with stemness, invasiveness, and resistance to chemotherapy, but the role of PrPC in tumor response to rad...

In Vivo Monitoring of Polycythemia Vera Development Reveals Carbonic Anhydrase 1 as a Potent Therapeutic Target. Le suivi in vivo du développement de la polycythémie vera révèle l'anhydrase carbonique 1 comme une cible thérapeutique potentielle

Archive ouverte | Murakami, Shohei | CCSD

International audience. Abstract Current murine models of myeloproliferative neoplasms (MPNs) cannot examine how MPNs progress from a single bone marrow source to the entire hematopoietic system. Thus, using transpl...

Multi-target mode of action of Sulfodyne ® , a stabilized Sulforaphane, against pathogenic effects of SARS-CoV-2 infection

Archive ouverte | Romeo, Paul-Henri | CCSD

Abstract The coronavirus disease 2019 (COVID-19) due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown that, except vaccination, few therapeutics options for its treatment or prevention are available. A...

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