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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

Archive ouverte | Dahlet, Thomas | CCSD

International audience. In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here,...

Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells

Archive ouverte | Al Adhami, Hala | CCSD

International audience. In mammals, many germline genes are epigenetically repressed to prevent their illegitimate expression in somatic cells. To advance our understanding of the mechanisms restricting the expressi...

A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates

Archive ouverte | Al Adhami, Hala | CCSD

International audience. Background: Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylation have been extensively studied in mou...

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