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Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication

Archive ouverte | Galupa, Rafael | CCSD

International audience. The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors (e.g. CTCF) underlying topologically ass...

Inversion of a topological domain leads to restricted changes in its gene expression and affects inter-domain communication

Archive ouverte | Galupa, Rafael | CCSD

The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors underlying genome topology, such as CTCF and cohesin, leads to modest alteratio...

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

Archive ouverte | Borensztein, Maud | CCSD

International audience. X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is...

Chargement des enrichissements...