Syracuse

Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

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Tachikart, Yassin | Malaise, Olivier | Mumme, Marcus | Jorgensen, Christian | Brondello, Jean-Marc

Edité par CCSD ; Elsevier -

International audience. Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. In this review, we will summarize the current knowledge on cellular senescence, list the different strategies for identifying seno-suppressive therapeutic agents and their translations to rheumatic diseases.

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