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Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection

Archive ouverte | Parez, Nathalie | CCSD

International audience. To evaluate whether the rectal route of immunization may be used to provide appropriate protection against enteric pathogens such as rotaviruses (RV), we studied the antibody response and the...

Secretory IgA directed to the inner core rotavirus VP6 protein contributes to protection via intracellular neutralization but not via immune exclusion

Archive ouverte | Corthésy, B | CCSD

International audience

The VP6 protein of rotavirus interacts with a large fraction of human naive B cells via surface immunoglobulins

Archive ouverte | Parez, Nathalie | CCSD

International audience. Immunity to human group A rotavirus (RV), a major cause of viral gastroenteritis in infants, involves B lymphocytes that provide RV-specific antibodies. Additionally, some arguments suggest t...

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